NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

fluorine F 18 tetrafluoroborate
A radioconjugate composed of the sodium-iodide symporter (NIS; SLC5A5) ligand tetrafluoroborate (TFB) labeled with the radionuclide fluorine F 18, with potential use as an imaging agent for NIS-expressing cells upon positron emission tomography (PET). Upon administration, fluorine F 18 tetrafluoroborate targets, binds to, and is taken up by NIS, which is expressed on the surface of cells in the normal thyroid gland, lactating mammary gland and various tumors. Then, NIS-expressing cells can be visualized and NIS expression levels can be assessed using PET. Since iodides are taken up by NIS, this agent may predict the uptake of radioactive iodine by cancer cells. Check for active clinical trials using this agent. (NCI Thesaurus)