NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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autologous TCR-engineered T cells IMA201
A preparation of autologous T lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for an as of yet not identified tumor-associated antigen (TAA), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T cells IMA201 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:ACTengine IMA201
autologous T-cell receptor-engineered T cells IMA201
IMA201 autologous T lymphocytes
IMA201 T cells
Code name:IMA 201
IMA201
IMA-201