NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

autologous PBLs retrovirally-transduced with TCRs targeting neoantigens
Autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding T-cell receptors (TCRs) specific for a patient's individual and unique mutated antigens, with potential immunostimulating and antineoplastic activities. Tumor cells are analyzed to identify and isolate specific mutated tumor-associated antigens (TAAs) that are expressed by the patient's tumor cells; then T-cell receptor coding sequences are engineered to target the patient's TAAs and inserted into retroviral vectors. After transduction, expansion in culture, and reintroduction into the patient, neoantigen-specific TCRs retroviral vector-transduced autologous PBLs recognize and bind to tumor cells expressing the patient's neoantigens, which results in a specific cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:autologous PBLs expressing mutated neoantigen-specific T-cell receptors
autologous peripheral blood lymphocytes retrovirally-transduced with TCRs targeting neoantigens
individual patient TCR-transduced autologous PBLs
neoantigen-reactive TCRs-transduced autologous PBLs
neoantigen-specific TCRs gene-transduced autologous PBLs