NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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anti-CD38/CD3 bispecific monoclonal antibody GBR 1342
A humanized, bispecific monoclonal antibody (BsAb) against human CD3, a T-cell surface antigen, and the human cell surface glycoprotein CD38, a tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, anti-CD38/anti-CD3 bispecific monoclonal antibody GBR 1342 binds to both CD3 on T cells and CD38 expressed on certain tumor cells. This results in the cross-linking of T cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis. GBR 1342 uses the proprietary bispecific engagement by antibodies based on the T-cell receptor (BEAT) platform. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:anti-CD38 x anti-CD3 bispecific monoclonal antibody GBR 1342
anti-CD38/anti-CD3 bispecific monoclonal antibody GBR 1342
BEAT GBR 1342
CD38xCD3 BsAb GBR 1342
Code name:GBR 1342
GBR1342
GBR-1342