NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

carbon C 14 pevonedistat
An orally bioavailable radioconjugate composed of pevonedistat, a small molecule inhibitor of NEDD8-activating enzyme (NAE), radiolabeled with the radioisotope carbon C 14, with potential use for evaluating the pharmacokinetic profile of pevonedistat. Pevonedistat binds to and inhibits NAE, which results in the inhibition of tumor cell proliferation and survival. Labeling of pevonedistat with the radioactive tracer carbon C 14 allows for the evaluation of pevonedistat's pharmacokinetic profile, including its absorption, distribution, metabolism, and excretion (ADME). Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:[14 C]-pevonedistat
carbon C 14-pevonedistat