androgen receptor antagonist ONC1-0013B
An orally bioavailable antagonist of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration, AR antagonist ONC1-13B specifically binds to AR, prevents AR activation, downregulates AR expression and prevents AR-mediated signaling. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells.
| Synonym: | AR antagonist ONC1-0013B |
|---|---|
| Code name: | ONC 10013B ONC 113 B ONC 113B ONC-10013B ONC1-0013B ONC1-13B ONC10013B ONC113B |
| Chemical structure: | (R)-4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-4-oxo-2-thioxo-7-oxa-1,3-diazaspiro[4.4]nonan-1-yl)-2-fluoro-N-methylbenzamide |