NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

anti-CD20/CD3 bispecific monoclonal antibody RO7082859
A bispecific monoclonal antibody, with potential antineoplastic activity. Anti-CD20/CD3 monoclonal antibody RO7082859 contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen, and one for human CD20, a tumor-associated antigen (TAA) that is exclusively expressed on B cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, RO7082859 binds to both T cells and CD20-expressing B-lineage tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD20-expressing tumor B cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:anti-CD20 x anti-CD3 bispecific monoclonal antibody RO7082859
Code name:RO 7082859