NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

carbon C 11-JNJ-63779586
A radioconjugate composed of JNJ-63779586 labeled with the positron-emitting isotope carbon C 11, with potential use in imaging via positron emission tomography (PET). Upon administration of carbon C 11-JNJ-63779586, the JNJ-63779586 moiety acts as a substrate for the efflux transporter P-glycoprotein (P-gp) and the breast cancer resistance protein (BCRP). Upon PET imaging, this radioligand may allow for the assessment of P-gp and BCRP function and expression in tumors. As P-gp and BCRP activity may influence response to therapy, measuring P-gp and BCRP activity may be beneficial when choosing chemotherapy. P-gp and BCRP, efflux transporters, are overexpressed by certain tumor cells and may contribute to multidrug resistance to chemotherapy. Check for active clinical trials using this agent. (NCI Thesaurus)