ciltacabtagene autoleucel
View Patient InformationA preparation of autologous T lymphocytes that are transduced, ex vivo, with LCAR-B38M, a lentiviral vector expressing a chimeric antigen receptor (CAR) containing two bispecific anti-B-cell maturation antigen (BCMA) variable fragments of llama heavy-chain murine antibodies fused to the signaling domain of 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. The antigen-binding region of the CAR is a non-scFv structure targeting two distinct regions of BCMA. Upon intravenous administration back into the patient, ciltacabtagene autoleucel are directed to cells expressing BCMA, bind to two different epitopes on BCMA and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-associated antigen (TAA) and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is overexpressed on malignant plasma cells.
Synonym: | autologous anti-BCMA CAR T Cells JNJ-68284528 autologous bi-epitope BCMA-targeted CAR T cells JNJ-68284528 autologous bi-epitope CAR T cells JNJ-68284528 cilta-cel LCAR-B38M-transduced CAR T Cells JNJ-68284528 |
---|---|
US brand name: | Carvykti |
Code name: | JNJ-68284528 LCAR-B38M |