NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

allogeneic interleukin-17-producing CD8-positive T cells
A preparation of allogeneic human cytotoxic T lymphocytes that express the pro-inflammatory cytokine interleukin-17 (IL-17; IL17), with potential immunomodulating and anti-tumor activities. Upon ex vivo stimulation, the IL-17-producing CD8-positive T cells (Tc17) convert to interferon-gamma (IFNg; IFN-g)-producing CD8-positive T cells (Tc1). Tc1 cells exert enhanced anti-tumor cytotoxicity. Human Tc17 cells may contribute to a number of human inflammatory and malignant diseases. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:allogeneic IL-17+ CD8 T cells
allogeneic IL-17-producing CD8+ T cells
allogeneic Tc17 cells