NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- allogeneic most closely HLA-matched adenovirus-specific cytotoxic T lymphocytes
A population of off the shelf, closely human leukocyte antigen (HLA)-matched allogeneic, ex vivo-expanded cytotoxic T lymphocytes (CTLs) specifically reactive to human adenovirus (Ad), with potential immunomodulating and anti-adenoviral activities. Upon administration, the allogeneic most closely HLA-matched Ad-specific CTLs may reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections either following allogeneic stem cell transplantation or in Ad-infected immunocompromised hosts. The anti-adenoviral CTLs are provided by a third party donor and not by the allogeneic stem cell transplant donor. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: most closely HLA-matched third-party donor adenovirus Specific CTLs
most closely HLA-matched third-party donor adenovirus-specific T cells