NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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fluorine F 18-AIF-NOTA-neurotensin
A radioconjugate containing neurotensin (NT) linked to the radionuclide fluorine F 18 (18F), by the macrocyclic chelating agent, 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), through a method that first couples 18F to aluminum (Al), with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18-Al-NOTA-neurotensin, the ligand moiety targets and binds to the neurotensin receptor (NTR). Upon PET/CT, NTR-expressing tumor cells can then be visualized and NTR tumor cell expression can be assessed, as well as the diagnosis and stage of cancer. The neuropeptide NT is overexpressed in certain types of cancers and plays a key role in tumor cell proliferation. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:[18F]AlF-NOTA-neurotensin
[18F]aluminum fluoride-1,4,7-triazacyclononane-1,4,7-triacetic acid-neurotensin
18F-AlF-NOTA-neurotensin
18F-AlF-NOTA-NT
18F-aluminum fluoride-1,4,7-triazacyclononane-1,4,7-triacetic acid-neurotensin
fluorine F 18-Al-NOTA-neurotensin