NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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fluorine F 18 DASA-23
A radiotracer composed of DASA-23, a pyruvate kinase isoform M2 (PKM2) ligand, conjugated to the radioisotope fluorine F 18, with potential use for imaging of PKM2-expressing tumor cells upon positron emission tomography (PET). Upon administration of fluorine F 18 DASA-23, the DASA-23 moiety selectively targets and is taken up by tumor cells that express PKM2. Upon binding to PKM2 and following PET, PKM2-expressing tumor cells can be visualized and the metabolic activity of the tumor cells can be assessed through the quantitation of PKM2 expression levels. PKM2, an enzyme that plays a key role in the glycolytic reprogramming, metabolic activity and rapid proliferation of tumor cells, is selectively overexpressed in various tumor cell types. Tumor uptake of fluorine F 18 DASA-23 is positively correlated with PKM2 expression. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:18F-DASA-23
F18-labeled PKM2 inhibitor DASA-23
F18-labeled pyruvate kinase M2 inhibitor DASA-23
Chemical structure:1-((2-fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine