NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

anti-CEACAM6 antibody BAY1834942
A humanized monoclonal antibody directed against the immune checkpoint regulator carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6; CEACAM-6; CD66c), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CEACAM6 antibody BAY1834942 targets, binds to and blocks the activity of CEACAM6 expressed on various tumor and immune cells, including T cells. Blocking CEACAM6 signaling abrogates effector T-cell inhibition, activates antigen-specific T lymphocytes, increases secretion of T-cell cytokines and effector molecules, and enhances cytotoxic T-cell-mediated tumor cell lysis, which results in a reduction in tumor cell proliferation. CEACAM6, an immune checkpoint receptor, is associated with tumor-mediated immune suppression. Elevated CEACAM6 expression is associated with advanced tumor stages and poor prognosis. Check for active clinical trials using this agent. (NCI Thesaurus)

Code name:BAY 1834942