NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

furosemide/digoxin topical gel CLS003
A topical ionic contra-viral therapy (ICVT) gel-based formulation that combines furosemide, a sulfamoylanthranilic acid derivative and loop diuretic, and digoxin, a cardiac glycoside, with potential antiviral activity. Upon topical administration, furosemide interacts with the cell membrane ion co-transporter, Na+-K+-2Cl-co-transporter-1(NKCC1; SLC12A2) and digoxin reversibly inhibits the sodium/potassium-transporting ATPase, leading to a decrease in potassium influx. This may prevent the replication of certain DNA viruses including human papillomavirus (HPV), that rely on potassium for replication. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:digoxin-furosemide topical gel CLS003
ICVT product CLS003
Code name:CLS 003