NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- anti-CD3/CD20 bispecific antibody GEN3013
A bispecific monoclonal antibody, with potential immunomodulating and antineoplastic activities. Anti-CD20/CD3 monoclonal antibody GEN3013 contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen, and one for human CD20, a tumor-associated antigen (TAA) that is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, GEN3013 binds to both T cells and CD20-expressing B-lineage tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD20-expressing tumor B cells. Check for active clinical trials using this agent. (NCI Thesaurus)
US brand name: DuoBody-CD3xCD20 Code name: GEN 3013