NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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anti-CD3/CD20 bispecific antibody GEN3013
A bispecific monoclonal antibody, with potential immunomodulating and antineoplastic activities. Anti-CD20/CD3 monoclonal antibody GEN3013 contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen, and one for human CD20, a tumor-associated antigen (TAA) that is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, GEN3013 binds to both T cells and CD20-expressing B-lineage tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD20-expressing tumor B cells. Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name:DuoBody-CD3xCD20
Code name:GEN 3013
GEN3013
GEN-3013