NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

anti-PSMA/CD28 bispecific antibody REGN5678
A bispecific antibody directed against both the tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA) and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration of anti-PSMA/CD28 bispecific antibody REGN5678, this bispecific antibody binds to both CD28 on cytotoxic T lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, which may result in the CTL-mediated cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:anti-PSMA/anti-CD28 bispecific antibody REGN5678
anti-PSMAxCD28 antibody REGN5678
Code name:REGN 5678