NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

samarium Sm 153-DOTMP
A radioconjugate composed of the phosphonic acid chelator DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid) conjugated to the beta- and gamma-emitting radioisotope samarium Sm 153, with potential antineoplastic activity. Upon administration of samarium Sm 153-DOTMP, the DOTMP moiety targets and binds to growing bone, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to bone tumor and metastases, which may help destroy bone metastases and mitigate pain from bone metastases. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:153 Sm-DOTMP
US brand name:CycloSam
Chemical structure:
  • Sm-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylene)phosphonic acid
  • Sm-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis(methylene)tetrakisphosphonic acid