NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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actinium Ac-225 anti-PSMA monoclonal antibody J591
A radioimmunoconjugate consisting of a humanized monoclonal antibody directed against prostate specific membrane antigen (PSMA) labeled with the alpha particle-emitting radioisotope actinium Ac-225, with potential antineoplastic activity. Upon administration, actinium Ac-225 anti-PSMA monoclonal antibody J591 binds to the extracellular domain of PSMA with high affinity, thereby delivering alpha radiation to PSMA expressing cells. PSMA, a type II membrane protein expressed in all types of prostatic tissues, is often overexpressed in tumor cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:Ac 225 MOAB J591
Ac 225 monoclonal antibody J591
actinium Ac-225 anti-prostate-specific membrane antigen monoclonal antibody J591
Abbreviation:225Ac-J591