NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

actinium Ac 225-FPI-1434
A radioimmunoconjugate composed of FPI-1175 (AVE1642), a humanized monoclonal antibody against insulin-like growth factor-1 receptor (IGF-1R), linked, via the bifunctional chelate FPI-1397, to the alpha-emitting radioisotope actinium-225 (225Ac or Ac-225), with potential antineoplastic activity. Upon administration of actinium Ac 225-FPI-1434, the FPI-1434 moiety targets and binds to IGF-1R expressed on tumor cells. In turn, Ac-225 emits alpha particles, thereby specifically killing the IGF-1R-expressing tumor cells while sparing normal, healthy cells. The linker promotes increased clearance of the radioisotope. Check for active clinical trials using this agent. (NCI Thesaurus)

actinium Ac 225-FPI-1397-FPI-1175
actinium Ac 225-labeled FPI-1434
Code name:[225Ac]-FPI-1434
FPX 01