NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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actinium Ac 225-FPI-1434
A radioimmunoconjugate composed of FPI-1175 (AVE1642), a humanized monoclonal antibody against insulin-like growth factor-1 receptor (IGF-1R), linked, via the bifunctional chelate FPI-1397, to the alpha-emitting radioisotope actinium-225 (225Ac or Ac-225), with potential antineoplastic activity. Upon administration of actinium Ac 225-FPI-1434, the FPI-1434 moiety targets and binds to IGF-1R expressed on tumor cells. In turn, Ac-225 emits alpha particles, thereby specifically killing the IGF-1R-expressing tumor cells while sparing normal, healthy cells. The linker promotes increased clearance of the radioisotope. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:[Ac-225]-FPI-1434
225Ac-FPI-1434
actinium Ac 225-FPI-1397-FPI-1175
actinium Ac 225-labeled FPI-1434
Code name:[225Ac]-FPI-1434
FPX 01
FPX01
FPX-01