NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

activin type IIA receptor Fc fusion protein KER-050
A recombinant fusion protein composed of a modified form of the ligand-binding domain of the human transforming growth factor beta (TGF-b) receptor activin receptor type IIA (ActRIIA) and linked to the Fc domain of human antibody, with red blood cell (RBC) and platelet stimulating activities. Upon subcutaneous administration, activin type IIA receptor Fc fusion protein KER-050 acts as a ligand trap, and binds to a subset of the TGF-b family of proteins. This inhibits the binding of these proteins to their receptors and blocks signaling mediated by this subset of TGF-b family of proteins and their receptors. This may promote hematopoiesis and increase RBC and platelet production. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:activin type 2A receptor Fc fusion protein KER-050
Code name:KER 050