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adenovirus HER2-transduced autologous dendritic cell vaccine

A cell-based cancer vaccine composed of autologous dendritic cells (DCs) transduced with a replication-deficient adenovirus vector encoding HER-2 with potential antineoplastic activity. Upon administration, adenovirus HER2-transduced autologous dendritic cell vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against HER-2-positive tumor cells, which may result in tumor cell death and decreased tumor growth. HER-2, a tyrosine kinase receptor for epidermal growth factor (EGF) (also known as neu and ErbB2), is overexpressed by some breast, ovarian, and gastric cancers.
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Synonym:autologous dendritic cell-adenovirus HER2 vaccine
autologous dendritic cell/adenovirus HER-2 vaccine
HER-2 pulsed DC vaccine
Abbreviation:AdHer2/DC
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