NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes
A preparation of allogeneic Epstein-Barr virus (EBV) specific cytotoxic T-lymphocytes (CTL) with potential antineoplastic activity. The allogeneic EBV-specific CTLs are either harvested from a donor with an EBV-positive tumor or are donor CTLs activated against EBV-specific antigens ex vivo. Administration into a patient exerts a CTL response against EBV-positive tumor cells or EBV-infected cells. This results in cell lysis and inhibition of cancer cell proliferation. EBV, a ubiquitous human herpes virus, is associated with various malignancies, including nasopharyngeal carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other lymphomas. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:allogeneic EBV-specific CTL