NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

allogeneic GM-CSF-secreting breast cancer vaccine SV-BR-1-GM
A vaccine consisting of irradiated allogeneic breast cancer cells, derived from the breast cancer cell line SV-BR-1 that are transfected with the immunostimulant granulocyte-macrophage colony-stimulating factor (GM-CSF; CSF2) gene, with potential immunostimulating and antineoplastic activities. Upon intradermal administration of the allogeneic GM-CSF-secreting breast cancer vaccine SV-BR-1-GM, the genetically-modified cells secrete GM-CSF. This potentiates a tumor-specific cytotoxic T-lymphocyte (CTL) immune response against breast cancer cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:GM-CSF gene-transfected breast cancer vaccine SV-BR-1-GM
SV-BR-1 breast cancer cell line vaccine
SV-BR1-GM breast cancer vaccine
SV-BR-1-GM vaccine
US brand name:Bria-IMT