Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

allogeneic multivirus-specific cytotoxic T lymphocytes

A population of closely human leukocyte antigen (HLA)-matched, donor-derived cytotoxic T lymphocytes (CTLs) that are specifically reactive towards five viruses, Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus (AdV), human herpesvirus 6 (HHV6), and human polyomavirus type I (BKV), with potential antiviral activity. Infusion of the multivirus-specific CTLs into allogeneic hematopoietic stem cell transplant (HSCT) recipients provides virus-specific cellular immunity and causes specific anti-viral effects against active viral infections. The administered CTLs also prevent EBV, CMV, AdV, HHV6, and BKV reactivation and infection as well as inhibiting viral-associated diseases in immunocompromised patients. The allogeneic multivirus-specific CTLs may also provide cellular immunity towards the human polyomavirus type II (JC virus; JCV), which is highly homologous to BKV.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:allogeneic EBV/CMV/AdV/HHV6/BKV-specific CTLs
allogeneic multivirus-specific CTLs
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search