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alteplase

A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.

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Synonym:	plasminogen activator (human tissue-type protein moiety) recombinant tissue plasminogen activator t-PA
US brand name:	Activase
Abbreviation:	rt-PA

alteplase

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