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alteplase

A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.
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Synonym:plasminogen activator (human tissue-type protein moiety)
recombinant tissue plasminogen activator
t-PA
US brand name:Activase
Abbreviation:rt-PA
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