Skip to main content

Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

aminopterin

A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis.

Check for active clinical trials using this agent View this agent in the NCI Thesaurus

Synonym:	4-amino-PGA 4-aminofolic acid 4-aminopteroyl-glutamic Acid 4-aminopteroylglutamic acid aminopteroylglutamic acid
Abbreviation:	APGA

aminopterin

Search NCI's Drug Dictionary