NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

An aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death. This agent's cytotoxicity is maximal during the S phase of the cell cycle when topoisomerase levels are greatest. In addition, amsacrine may induce transcription of tumor promoter p53 protein and block p53 ubiquitination and proteasomal degradation, resulting in p53-dependent tumor cell apoptosis. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:acridinyl anisidide
Cain's Acridine
US brand name:Amsa P-D
Foreign brand name:Amekrin
Code name:CI-880
Chemical structure:
  • 4'-(9-acridinylamino)methane-sulfon-m-anisidide
  • N-[4-(9-acridinylamino)-3-methoxyphenyl]methanesulfonamide