NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- anti-CTLA4 mAb RNA/GITRL RNA-transfected autologous dendritic cell vaccine
An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. Anti-CTLA4 MoAb RNA/GITRL RNA-transfected DC vaccine is prepared by transfecting DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic T-Lymphocyte-Associated Antigen 4) monoclonal antibody and tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of anti-CTLA4 blocks the inhibitory effect of CTLA4 on the activation of T-lymphocytes, while expression of GlTRL modulates T lymphocyte survival in peripheral tissues. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: anti-CTLA-4 mAb heavy and light chain RNA/GITRL RNA-transfected autologous DC
anti-CTLA-4 mAb heavy and light chain RNA/GITRL RNA-transfected autologous dendritic cell
anti-CTLA4 MoAb RNA/GITRL RNA-transfected autologous dendritic cell vaccine
Abbreviation: GITRL/antiCTLA4 RNA DC