NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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anti-FCRH5/CD3 BiTE antibody BFCR4350A
A proprietary recombinant bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) Fc receptor-like protein 5 (FCRH5; CD307; FCRL5; IRTA2; BXMAS1) and one that is directed against the CD3 antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of anti-FCRH5/CD3 BiTE antibody BFCR4350A, the bispecific antibody binds to both the CD3 antigen on cytotoxic T lymphocytes (CTLs) and FCRH5 found on FCRH5-expressing tumor cells. This activates and crosslinks CTLs with FCRH5-expressing tumor cells, which results in the CTL-mediated cell death of FCRH5-expressing tumor cells. FCRH5, an immune receptor translocation-associated protein/Fc receptor homolog (IRTA/FCRH) family member and a B-cell lineage marker, is overexpressed on myeloma cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:anti-FCRH5 × anti-CD3 bi-specific T-cell engager BFCR4350A
anti-FCRH5/CD3 TDB BFCR4350A
FCRH5/CD3 T cell-dependent bispecific antibody BFCR4350A
FCRH5/CD3 TDB antibody BFCR4350A
recombinant anti-FCRH5 × anti-CD3 bi-specific T-cell engager BFCR4350A
Code name:BFCR4350A
RO7187797