NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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anti-glypican 3-scFvGC33-CAR-expressing T lymphocytes
A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from the anti-glypican-3 (GPC3) monoclonal antibody GC33 (scFvGC33), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-scFvGC33-CAR autologous T lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells.. GPC3 plays an important role in cellular proliferation and differentiation. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:anti-GPC3-scFvGC33-CAR autologous T lymphocytes
autologous GAP T cells
autologous GPC3-CAR T cells
glypican 3-specific chimeric antigen receptor expressed in autologous T cells
glypican 3-specific chimeric antigen receptor-expressing autologous T cells