NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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anti-HER2-vc0101 ADC PF-06804103
A proprietary antibody-drug conjugate (ADC) composed of a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) site-specifically linked, via a protease cleavable linker, to an analog of dolastatin 10, Auristatin-0101, with potential antineoplastic activity. Upon administration, anti-HER2-vc0101 ADC PF-06804103 targets HER2 expressed on tumor cells. Upon binding, internalization and cleavage, Auristatin-0101 binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and apoptosis of HER2-expressing tumor cells. HER2, a tumor-associated antigen (TAA), is overexpressed on a variety of cancer cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:antibody-drug conjugate PF-0680410
anti-HER2-vcAur0101 ADC PF-06804103
anti-NG-HER2 ADC PF-06804103
anti-NG-Her2-vc0101 ADC PF-06804103
Code name:PF 06804103
PF06804103
PF-068041033