NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

anti-HLA-A2/NY-ESO-1 TCR-transduced autologous T lymphocytes
Autologous human peripheral blood T lymphocytes transduced with a lentiviral or retroviral vector encoding a human leukocyte antigen A2 (HLA-A2)-restricted anti-cancer-testis antigen 1 (NY-ESO-1) T-cell receptor (TCR) gene, with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and re-introduction into the patient, the anti-HLA-A2/NY-ESO-1 TCR-transduced autologous T lymphocytes recognize and bind to NY-ESO-1/HLA-A2-positive tumor cells. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:anti-HLA-A2/NY-ESO1 TCR-transduced autologous T cells
autologous anti-HLA-A2/NY-ESO1 TCR-transduced T lymphocytes
autologous HLA-A2/NY-ESO-1-specific TCR gene-transduced T lymphocytes