NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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anti-OX40 antibody PF-04518600
An agonistic antibody that recognizes the co-stimulatory receptor OX40 (CD134;TNFRSF4), with potential immunostimulatory activity. Upon administration, anti-OX40 antibody PF-04518600 selectively binds to and activates OX40; which induces proliferation of memory and effector T-lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote a T-cell-mediated immune response against TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation. Check for active clinical trials using this agent. (NCI Thesaurus)

Code name:PF-04518600