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anti-PLGF monoclonal antibody TB-403

A humanized immunoglobulin (Ig) G1 monoclonal antibody directed against the placenta growth factor (PGF), with potential anti-angiogenic and antineoplastic activities. Anti-PGF monoclonal antibody TB-403 binds to both PGF-1 and -2, thereby inhibiting the binding of PGF-1 and -2 to the vascular endothelial growth factor receptor-1 (VEGFR-1) and subsequent VEGFR-1 phosphorylation. This may result in the inhibition of tumor angiogenesis and tumor cell proliferation. PGF, a member of the VEGF sub-family and a key molecule in angiogenesis and vasculogenesis, is upregulated in many cancers.
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Synonym:anti-PGF monoclonal antibody RO5323441
anti-placental growth factor monoclonal antibody TB-403
Code name:RG7334
RO5323441
TB-403
THR 317
THR-317
THR317
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