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anti-VEGF/ANG2 nanobody BI 836880

A nanobody directed against angiopoietin-2 (Ang2; ANGPT2)- and vascular endothelial growth factor (VEGF)-derived peptides, with potential antiangiogenic and antineoplastic activities. Anti-VEGF/ANG2 nanobody BI 836880 binds to Ang2 and VEGF and inhibits receptor binding; this prevents Ang2- and VEGF-mediated signaling and inhibits both tumor angiogenesis and tumor cell proliferation. Both VEGF and Ang2 are upregulated in a variety of cancer cell types and each plays a crucial role in angiogenesis. The nanobody is based on functional fragments of single-chain antibodies.
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Synonym:anti-VEGF/ANG2 BI 836880
bi-specific anti-VEGF/Ang2 nanobody BI 836880
Code name:BI 836880
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