NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- antibody-drug conjugate anti-TIM-1-vcMMAE CDX-014
A human immunoglobulin G1 (IgG1) monoclonal antibody-drug conjugate (ADC) targeting the extracellular domain of T-cell immunoglobulin mucin-1 (TIM-1) (clone CR014) and linked, via a valine-citrulline (vc) peptide linker, to the potent cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of ADC Anti-TIM-1-vcMMAE CDX-014, the monoclonal antibody moiety targets and binds to TIM-1. Upon internalization and proteolytic cleavage, MMAE is released into the cytosol of TIM-1-expressing tumor cells, binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis. TIM-1 is upregulated in a variety of cancer cell types while only minimally expressed in healthy tissue. The linkage system in CDX-014 is highly stable in plasma, resulting in cytotoxic specificity for TIM-1-positive cells. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: ADC anti-TIM-1-vcMMAE CDX-014
antibody-drug conjugate CDX-014
Code name: CDX-014