NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- antigen-targeted personalized breast cancer vaccine
An individualized, therapeutic cancer vaccine (IVAC) composed of liposomes containing RNA encoding two or three tumor-associated antigens (TAAs) that are specifically expressed in the patient's individual cancer selected from a warehouse (“off the shelf”) and p53 RNA, with potential immunostimulatory and antineoplastic activities. Upon administration, the antigen-targeted personalized breast cancer vaccines are translated by antigen presenting cells (APCs) and the expressed protein is presented via major histocompatibility complex (MHC) molecules on the surface of the APCs. This leads to an induction of both cytotoxic T-lymphocyte (CTL) and memory T-cell immune responses against the TAAs. The RNAs in the vaccine are specifically selected for an individual patient after RNA profiling of the patient’s tumor. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: IVAC_W_bre1_uID Foreign brand name: IVAC ® Warehouse vaccine