arsenic trioxide
View Patient InformationA small-molecule arsenic compound with antineoplastic activity. The mechanism of action of arsenic trioxide is not completely understood. This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic.
| Synonym: | arsenic (III) oxide arsenic sesquioxide arsenous acid arsenous acid anhydride arsenous oxide white arsenic |
|---|---|
| US brand name: | Trisenox |
| Abbreviation: | ATO |