NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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AXL/cMET receptor tyrosine kinase inhibitor BPI-9016M
An orally available inhibitor of the receptor tyrosine kinases AXL (UFO) and c-MET/hepatocyte growth factor receptor (HGFR) with antineoplastic activity. Upon administration, AXL/c-MET receptor tyrosine kinase inhibitor BPI-9016M, binds to both AXL and c-MET, thereby disrupting both AXL- and c-MET-mediated signaling pathways. Altogether, this agent inhibits growth in AXL- and c-MET-overexpressing tumor cells. AXL, a member of the TAM (TYRO3, AXL and MER) family of receptor tyrosine kinases, and c-MET, both overexpressed by many tumor cell types, play key roles in tumor cell proliferation, survival, invasion and metastasis. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:AXL receptor tyrosine kinase/c-MET inhibitor BPI-9016M
AXL/cMET inhibitor BPI-9016M
Code name:BPI 9016
BPI-9016
BPI-9016M