NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

AXL/cMET receptor tyrosine kinase inhibitor BPI-9016M
An orally available inhibitor of the receptor tyrosine kinases AXL (UFO) and c-MET/hepatocyte growth factor receptor (HGFR) with antineoplastic activity. Upon administration, AXL/c-MET receptor tyrosine kinase inhibitor BPI-9016M, binds to both AXL and c-MET, thereby disrupting both AXL- and c-MET-mediated signaling pathways. Altogether, this agent inhibits growth in AXL- and c-MET-overexpressing tumor cells. AXL, a member of the TAM (TYRO3, AXL and MER) family of receptor tyrosine kinases, and c-MET, both overexpressed by many tumor cell types, play key roles in tumor cell proliferation, survival, invasion and metastasis. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:AXL receptor tyrosine kinase/c-MET inhibitor BPI-9016M
AXL/cMET inhibitor BPI-9016M
Code name:BPI 9016