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Aziridinylbenzoquinone RH1

A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors.
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Code name:RH1
Chemical structure:2,5-Diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone
2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone
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