NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- anti-ICAM-1 monoclonal antibody BI-505
A fully human IgG1 monoclonal antibody directed against intercellular adhesion molecule-1 (ICAM-1 or CD54), with potential antineoplastic activity. Anti-ICAM-1 monoclonal antibody BI-505 selectively binds to the adhesion protein ICAM-1, which may result in antibody-dependent cellular cytotoxicity (ADCC), hyper-cross-linking-induced apoptosis, and a decrease in cellular proliferation of ICAM-1-expressing tumor cells.
ICAM-1, normally expressed on leukocytes and endothelial cells, may be overexpressed in a variety of cancers. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: anti-intercellular adhesion molecule-1 monoclonal antibody BI-505 Code name: BI-505