biricodar dicitrate
The dicitrate salt of a synthetic pipecolinate derivative with potential chemosensitizing activity. Biricodar binds directly to the plasma membrane drug-efflux pumps P-glycoprotein (Pgp) and multidrug resistance protein 1 (MRP-1) and inhibits their activities, which may result in increased intracellular accumulation and retention of cytotoxic agents.
| Synonym: | Incel VX-710 |
|---|---|
| US brand name: | Incel |
| Code name: | VX-710 |
| NSC code: | 724636 |