bisantrene hydrochloride
The hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the helical structure of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.
| Synonym: | bisantrene dihydrochloride orange crush |
|---|---|
| Foreign brand name: | Zantrene |
| Code name: | CL-216942 |
| Chemical structure: | 9,10-anthracenedicarboxakdehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride 9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-yl)hydrazone dihydrochloride 9,10,Anthracenedicarboxaldehyde dihydrochloride |