NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

bisantrene hydrochloride
The hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:bisantrene dihydrochloride
bisantrene HCL
orange crush
Foreign brand name:Zantrene
Code name:CL 216942
Chemical structure:
  • 9, 10-anthracenedicarboxaldehyde, bis(4, 5-dihydro-1H-imidazol-2-ylhydrazone),dihydrochloride
  • 9,10,Anthracenedicarboxaldehyde dihydrochloride
  • 9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-yl)hydrazone dihydrochloride