Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

bisantrene hydrochloride

The hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the helical structure of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:bisantrene dihydrochloride
orange crush
Foreign brand name:Zantrene
Code name:CL-216942
Chemical structure:9,10-anthracenedicarboxakdehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride
9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-yl)hydrazone dihydrochloride
9,10,Anthracenedicarboxaldehyde dihydrochloride
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search