BL22 immunotoxin
A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity. BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells.
Synonym: | anti-CD22 recombinant immunotoxin BL22 BL22 BL22 Immunotoxin [RFB4(dsFv)-PE38] RFB4(dsFv)-PE38 immunotoxin |
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Abbreviation: | BL22 |
Code name: | CAT 3888 CAT-3888 CAT3888 GCR-3888 |