brontictuzumab
A humanized monoclonal antibody directed against the Notch-1 receptor with potential antineoplastic activity. Upon administration, brontictuzumab binds to Notch-1 on the cell surface, thereby inhibiting Notch-mediated signaling and tumor cell proliferation. Notch 1, a type 1 transmembrane protein belonging to the Notch family, functions as a receptor for membrane bound ligands and has various roles during development; dysregulated Notch signaling is associated with increased cell growth and chemoresistance in cancers.
| Synonym: | anti-Notch1 monoclonal antibody OMP-52M51 immunoglobulin G2-lambda, anti-(homo sapiens Notch1 (Notch 1, translocation-associated Notch-1, TAN-1,Tan1)), humanized monoclonal antibody |
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| Code name: | OMP-52M51 |