NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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carbon C 13/nitrogen N 15-labeled valine
A radioconjugate composed of the essential amino acid valine radiolabeled to carbon C 13 and nitrogen N 15, that can potentially be used as a tracer for protein metabolism in vivo using mass spectrometry (MS). Upon administration of carbon C 13/nitrogen N 15-labeled valine, the exogenous valine is taken up by cells and incorporated into proteins. Upon imaging, protein biomarkers containing radiolabeled valine are secreted by tumor cells and can be identified by MS. This may aid in cancer diagnosis and prognosis. Compared to normal cells, tumor cells rapidly take up amino acids to use as protein building blocks. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:C13 N15 valine
carbonomic
Chemical structure:(+)-2-amino-3-methylbutyric Acid-13C5,15N (SY); L-valine-13C5,15N (SY); L-2-amino-3-methylbutanoic acid-13C5,15N