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carbon C 14 dacomitinib

A radioconjugate consisting of an orally bioavailable small-molecule inhibitor of the epidermal growth factor receptor (erbB or HER) family of tyrosine kinases radiolabeled with carbon-14 with potential antineoplastic and beta-emitting radioisotope activity. Dacomitinib specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors. The HER receptor family of tyrosine kinases, often overexpressed by a variety of tumor cell types, may contribute to tumor cell proliferation, differentiation, migration, and survival. Dacomitinib radiolabeled with carbon C-14 may be used as a radiotracer in pharmacological studies of dacomitinib metabolism.
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Synonym:[14C]PF-00299804
carbon C 14 PF-00299804
carbon C-14 dacomitinib
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