NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T lymphocytes
A preparation of genetically modified central memory (Tcm) enriched T cells transduced with a replication incompetent lentiviral vector expressing a chimeric antigen receptor (CAR), containing a CD28 signaling domain fused to both CD3 zeta, which targets the CD19 antigen, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity response. The costimulatory signaling domain enhances proliferation of T cells and antitumor activity. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells
CD19-CAR-specific/truncated EGFR lentiviral vector-transduced T cells
CD19R(EQ)28zeta/EGFRt+ TCM
CD19R(EQ)28zeta/truncated human EGFR+ central memory T cells
CD19R:CD28:lentiviral/EGFRt+ T cells